Nova Science Publishers, Inc.ISBN: 978-1-60741-391-2
Copyright © 2009 by Nova Science Publishers, Inc.
Book Description,
Differentiation is a complex multistep process that affects many biological pathways that regulate the expression of specific genes, and cell proliferation. All adult tissues are made up of lineages of cells consisting of tissue stem cells and their progeny (transit-amplifying cells and terminally differentiated cells). Recent data suggest that cancers arise from rare self-renewing stem cells that are biologically distinct from their more numerous differentiated progeny. Growing evidence suggests that pathways regulating normal stem cell self-renewal anddifferentiation are also present in cancer cells and cancer stem cells (CSCs). The unique properties of stem cells are opening the door to the development of new therapeutic approaches notably in oncology and regenerative medicine.
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Differentiation is a complex multistep process that affects many biological pathways that regulate the expression of specific genes, and cell proliferation. All adult tissues are made up of lineages of cells consisting of tissue stem cells and their progeny (transit-amplifying cells and terminally differentiated cells). Recent data suggest that cancers arise from rare self-renewing stem cells that are biologically distinct from their more numerous differentiated progeny. Growing evidence suggests that pathways regulating normal stem cell self-renewal anddifferentiation are also present in cancer cells and cancer stem cells (CSCs). The unique properties of stem cells are opening the door to the development of new therapeutic approaches notably in oncology and regenerative medicine.
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